Reflowable EPUB vs fixed-layout PDF: the real difference
A PDF is a stack of finished pages; an EPUB is a stream of structured text that each device lays out on the fly. That single difference decides everything downstream: page numbers exist in PDF but are meaningless in EPUB; a two-column worksheet survives in PDF and collapses in EPUB; a novel reads beautifully reflowed and feels rigid as fixed pages on a phone.
Choose by reading context. Screens smaller than the page favor EPUB. Content whose meaning depends on placement — forms, planners, illustrated spreads — needs PDF. Long prose intended for e-readers is EPUB by default.